Adams County's two most populous cities are Ritzville and Othello. Ritzville is located in the northeastern corner of the county at the junction of I-90 and US 395, making it a popular stop for travelers. Ritzville is an hour's drive from Spokane. Ritzville is the county seat.
In Othello, located in the southwestern corner of the county, State Routes 26, 17, and 24 converge. Othello is an hour's drive away from the Tri-Cities region, and a half hour drive to Moses Lake. Othello sees steady growth due to irrigation available from the Columbia Basin Project.